At PFRANKMD, we believe in optimizing your health from the inside out. Peptide therapy is a key component of our comprehensive approach to aesthetic and longevity medicine, supporting patients in achieving enhanced vitality, improved skin health, balanced hormones, and accelerated healing. Under the medical direction of Dr. Paul Jarrod Frank, peptide protocols are customized to each patient’s goals—whether that’s improved sleep, cognitive clarity, athletic performance, or graceful aging.
Peptide Therapy
Advancing Aesthetic and Longevity Healthcare with Peptide Therapy
What Are Peptides?
Peptides are short chains of amino acids that function as signaling molecules within the body, instructing cells to perform specific tasks. Naturally occurring peptides regulate critical biological processes including inflammation, tissue repair, metabolism, and hormone production. In peptide therapy, synthetic versions of these naturally occurring peptides are used to target and enhance those same physiological functions.
At PFRANKMD, we only utilize pharmaceutical-grade peptides sourced from trusted, accredited compounding pharmacies to ensure safety, efficacy, and consistency.
Why Peptide Therapy?
As we age, the natural production of key peptides in the body declines, contributing to fatigue, weight gain, reduced muscle tone, poor sleep, joint pain, and visible signs of aging. Peptide therapy addresses this decline by:
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Stimulating collagen production for firmer, more youthful skin
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Enhancing fat metabolism and muscle development
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Improving cognitive focus and memory
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Supporting hormone balance and libido
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Accelerating healing post-injury or procedure
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Promoting deeper, more restorative sleep
Targeted Peptides Available at PFRANKMD
Each peptide is selected based on your wellness goals. Some of the most utilized options in our aesthetic and longevity practice include:
Peptide Therapy for Muscle Growth, Athletic Performance & Recovery
CJC-1295: Promotes natural growth hormone release for fat loss and muscle gain.
Ipamorelin: Enhances recovery and supports lean muscle development.
BPC-157: Speeds healing and reduces inflammation in muscles and joints.
Sermorelin: Boosts natural HGH production with minimal side effects.
Peptide Therapy for Healthy Aging & Skin Repair
GHK-Cu: Improves skin elasticity, firmness, and wound healing.
Thymosin Alpha-1: Supports immune health and inflammation control.
Your expert provider will consider each of your aesthetic and longevity healthcare goals when designing your peptide protocol.
Peptide Therapy Delivery Methods
Peptides at PFRANKMD can be administered in several forms depending on patient preference and clinical goals:
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Subcutaneous injection
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Transdermal cream
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Nasal spray
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Oral tablets or capsules
Who Is a Candidate for Peptide Therapy?
Anyone looking to optimize their health, improve recovery, support graceful aging, or elevate energy and cognitive function may benefit from peptide therapy. Patients dealing with chronic fatigue, hormonal imbalance, post-COVID symptoms, perimenopause/menopause, and aesthetic skin concerns often experience meaningful improvements.
All treatment plans are designed following a comprehensive consultation to evaluate your medical history, lab results, and long-term goals.
Schedule a Consultation
Peptides are a powerful, scientifically backed tool in the evolving world of aesthetic and longevity healthcare. At PFRANKMD, we’re here to guide you through the latest innovations in regenerative medicine, always with your safety, results, and optimization in mind. Schedule your personalized consultation and discover how peptide therapy can help you feel and look your best.
SOCIAL MEDIA
After pregnancy, many women notice stretch marks as the skin stretches and tears to accommodate rapid change.
While the body does begin to repair itself naturally, stretch marks don’t always fade completely on their own.
Laser treatments can safely and effectively accelerate the healing process, improving skin texture, tone, and elasticity by stimulating collagen and skin regeneration.
As early as one month postpartum, or once your OB/GYN gives approval, laser therapy can be started. The sooner treatment begins, the better the results and often the fewer sessions needed.
Every body and every pregnancy is different, achieving optimal results may require a customized combination of advanced laser technologies tailored specifically to your skin.
If you’re ready to feel confident in your skin again and support your body’s recovery with expert care, call (212) 327-2919 to schedule a consultation and learn which stretch mark treatment is right for you.
𝐒𝐭𝐫𝐞𝐭𝐜𝐡 𝐌𝐚𝐫𝐤𝐬 & 𝐒𝐤𝐢𝐧 𝐋𝐚𝐱𝐢𝐭𝐲: 𝐕𝐛𝐞𝐚𝐦 + 𝐌𝐢𝐫𝐢𝐚
Stretch marks and skin laxity often develop as a result of pregnancy, weight fluctuations, or the natural aging process. At PFRANKMD, we combine the Vbeam laser and Miria laser to effectively address both concerns.
Miria uses advanced non-ablative laser technology to heat the deeper layers of the skin, improving elasticity and firmness by stimulating new collagen and elastin production.
Vbeam targets redness and discoloration in stretch marks by reducing vascular inflammation and stimulating collagen remodeling for a more even skin tone.
Together, these treatments work synergistically to reduce the appearance of stretch marks and restore smoother, tighter, and more youthful-looking skin with minimal downtime.
To learn more or schedule a consultation, call (212) 327-2919 or click the link in bio.
𝐄𝐥𝐥𝐚𝐜𝐨𝐫 𝐏𝐚𝐭𝐢𝐞𝐧𝐭 𝐓𝐞𝐬𝐭𝐢𝐦𝐨𝐧𝐢𝐚𝐥 | 𝟐𝟒 𝐇𝐨𝐮𝐫𝐬 𝐏𝐨𝐬𝐭-𝐏𝐫𝐨𝐜𝐞𝐝𝐮𝐫𝐞
Our patient shares her experience just 24 hours after her first Ellacor micro-coring treatment, highlighting how comfortable the procedure felt and why she chose Ellacor to tighten and sculpt her face with minimal downtime.
Erin, 45, describes the treatment as virtually painless, noting only a mild sunburn-like sensation 24 hours after the treatment. Her goal was natural-looking tightening and improved facial contour without surgery. At just one day post-procedure, she already felt confident about her decision and impressed by how manageable the recovery has been.
Planning for an event? While Ellacor has significantly less downtime than traditional surgical options, optimal results develop gradually as the skin rebuilds collagen and elastin. For best results, we recommend starting Ellacor at least 8–12 weeks before a major event, allowing time for healing, collagen stimulation, and refinement of results.
Some patients may benefit from a series of treatments depending on their skin goals and timeline.
Ellacor is ideal for patients seeking meaningful skin tightening with natural results. Call (212) 327-2919 or click the link in bio to schedule a consultation.
Forget salmon sperm, forget PDGF, forget exosomes, forget PRF for skin rejuvenation until hard data and the test of time prove otherwise. These treatments are largely experimental, unpredictable, and trend driven, lacking the proven regenerative foundation of fat.
Micro and nanofat stand apart as true regenerative tools, leveraging your body’s own fat and its rich concentration of stem cells and growth factors to improve skin quality, texture, tone, and structural integrity. By working with native tissue biology rather than foreign materials, this approach delivers natural, long-term rejuvenation and meaningful collagen remodeling under local anesthesia.
𝟐𝟎𝟐𝟔: 𝐓𝐡𝐞 𝐘𝐞𝐚𝐫 𝐨𝐟 𝐅𝐚𝐭 – 𝐑𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐚𝐧𝐝 𝐍𝐚𝐭𝐮𝐫𝐚𝐥 𝐁𝐞𝐚𝐮𝐭𝐲
Fat transfer was once a foundational part of my practice, before the rise of fillers and biostimulatory agents. Now, with advances in microfat and nanofat processing, fat-based treatments are experiencing a powerful resurgence and for good reason.
Fat is one of the most accessible and regenerative resources in the human body. Rich in stem cells and growth factors, it offers remarkable potential not only in aesthetics, but across regenerative medicine including orthopedic and cardiac applications. These innovations allow us to harness fat’s natural healing properties in a more refined, precise way, supporting skin quality, tissue regeneration, and long-term vitality.
As we move into 2026, I am increasingly focused on helping patients age better naturally, optimizing their appearance and health while minimizing reliance on foreign substances. This evolution reflects a broader shift toward regenerative, whole-body approaches that align beauty with longevity.
I am deeply grateful for my career, my patients, and the opportunity to continue advancing medicine in a way that supports natural beauty, resilience, and pro-aging from the inside out.
Featured in “Ozempic Body: Solutions for Sagging Skin” written by @ingridanneschmidt for @hollywoodreporter
The article explores how rapid weight loss from GLP‑1 medications like Ozempic, Wegovy, and Mounjaro can lead to accelerated facial aging — including sagging skin, hollow cheeks, and a more gaunt appearance. When weight drops quickly, fat volume in the face diminishes, skin loses elasticity, and collagen and elastin production slow down, leaving patients looking older than before.
One of the newer solutions highlighted is Ellacor fractional micro‑coring technology. This minimally invasive procedure uses hollow needles to remove thousands of micro‑cores of skin in a precise, grid‑like pattern while delivering controlled heat. As the skin heals, it tightens and contracts naturally — improving skin laxity, fine lines, and crepiness without the downtime or scarring associated with surgery. For many experiencing “Ozempic Face,” Ellacor can be combined with other treatments like fillers or collagen stimulators to both restore lost volume and firm loose skin.
“I see it every day in my office. A 50‑year‑old patient will come in, suddenly super‑skinny and needing filler for the first time. I ask, ‘How long have you been on Ozempic?’ and I’m right 100 % of the time.” – Dr. Paul Jarrod Frank
By understanding how medications affect skin and facial structure — and knowing that treatments like Ellacor exist — patients can take a proactive approach to maintaining a healthy, natural, and youthful look after weight loss.
𝐏𝐞𝐩𝐭𝐢𝐝𝐞𝐬 𝐚𝐧𝐝 𝐑𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞: 𝐀 𝐏𝐫𝐨-𝐀𝐠𝐢𝐧𝐠 𝐏𝐞𝐫𝐬𝐩𝐞𝐜𝐭𝐢𝐯𝐞 𝐨𝐧 𝐁𝐨𝐝𝐲 𝐑𝐞𝐣𝐮𝐯𝐞𝐧𝐚𝐭𝐢𝐨𝐧
I discuss the rapid rise of peptides and regenerative medicine and their growing role in body rejuvenation and longevity-focused care. I break down commonly discussed treatments derived from various biological sources, including exosomes and other bioactive compounds, and how they are marketed to stimulate the body’s natural repair and regeneration processes.
I also address the current limitations, potential risks, and regulatory concerns surrounding these therapies, including the lack of FDA approval for certain injectable treatments, emphasizing the importance of evidence-based medicine and responsible adoption of emerging technologies.
🎧 Listen to the full episode of The Pro-Aging Podcast to hear the complete conversation and my perspective on navigating regenerative medicine thoughtfully, safely, and with long-term outcomes in mind.
𝐓𝐡𝐞 𝐏𝐫𝐞𝐦𝐚𝐭𝐮𝐫𝐞 𝐏𝐫𝐨𝐦𝐢𝐬𝐞 𝐨𝐟 𝐅𝐚𝐜𝐢𝐚𝐥 𝐏𝐥𝐚𝐬𝐭𝐢𝐜 𝐒𝐮𝐫𝐠𝐞𝐫𝐲: 𝐀 𝐏𝐫𝐨-𝐀𝐠𝐢𝐧𝐠 𝐃𝐞𝐫𝐦𝐚𝐭𝐨𝐥𝐨𝐠𝐢𝐬𝐭’𝐬 𝐏𝐞𝐫𝐬𝐩𝐞𝐜𝐭𝐢𝐯𝐞
In this episode, I discuss the growing trend of over-marketing facial plastic surgery to younger patients and the misconceptions surrounding so-called preventative procedures. I explain why surgical intervention in the early 40s can sometimes lead to suboptimal outcomes, including the need for unnecessary repeat surgeries over time.
I also break down the importance of skin health, collagen preservation, and non-surgical strategies as a first-line approach, emphasizing pro-aging, thoughtful care rather than rushing into invasive procedures before they are truly indicated.
🎧 Listen to the full S3E10 of The Pro-Aging Podcast to hear the complete episode, where I break down the biggest shifts in aesthetics in 2025 and share what I believe is coming next in 2026.
𝐓𝐡𝐞 𝐏𝐫𝐨-𝐀𝐠𝐢𝐧𝐠 𝐏𝐨𝐝𝐜𝐚𝐬𝐭: 𝟐𝟎𝟐𝟓 𝐘𝐞𝐚𝐫 𝐢𝐧 𝐑𝐞𝐯𝐢𝐞𝐰
We’re wrapping up the season with a special solo episode.
In this final episode, I break down the biggest shifts in aesthetic medicine in 2025 and what I believe is coming next in 2026, from injectable awakenings to surgical hype and the rise of regenerative medicine.
𝐖𝐞 𝐝𝐢𝐯𝐞 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐦𝐨𝐬𝐭 𝐭𝐚𝐥𝐤𝐞𝐝-𝐚𝐛𝐨𝐮𝐭 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐲𝐞𝐚𝐫, 𝐢𝐧𝐜𝐥𝐮𝐝𝐢𝐧𝐠:
✨ The rise of “filler fear” and why injectables still have a place when used responsibly
✨ The year of celebrity surgery and the deep plane facelift hype, plus why technique and timing matter
✨ Regenerative medicine and peptides, what’s promising, what’s over-marketed, and what needs more data
✨ Why the next 5 to 10 years will be the decade of maintenance, with lasers, resurfacing, and injectable-sparing technologies
✨ Why fat is poised to be the next major focus, and the resurgence of microfat and nanofat for regenerative results
To close, I share what I’m watching for 2026 and beyond as aesthetics continues moving toward smarter, safer, more natural pro-aging outcomes.
Thank you for listening all year. Your support is what makes this podcast possible. Here’s to a strong finish to 2025 and an even better 2026. 🥂
🎧 Click the link in bio to listen to the full episode and catch up on the rest of the season wherever you get your podcasts.
For more on pro-aging, check out my book, The Pro-Aging Playbook.
𝐆𝐞𝐧𝐭𝐥𝐞, 𝐄𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞 𝐋𝐄𝐃 𝐂𝐚𝐫𝐞 𝐟𝐨𝐫 𝐀𝐥𝐥 𝐒𝐤𝐢𝐧 𝐓𝐲𝐩𝐞𝐬
Annie, our Director of Operations and Creative Director at PFRANKMD, shares one of the ways our team supports skin health between in-office treatments.
This professional-grade at-home LED mask was selected by our providers with sensitive skin in mind and designed to deliver consistent, clinically studied light therapy without irritation or downtime. With multiple customizable light settings, it helps target concerns like breakouts, pigmentation, uneven texture, and early signs of aging.
Red, blue, and near-infrared wavelengths work together to support collagen production, calm inflammation, improve clarity, and enhance overall radiance. The flexible silicone design contours comfortably to the face, ensuring even light coverage in just 10 minutes per session.
Safe, gentle, and suitable for all skin types, the Lumiera PFRANKMD LED Mask brings spa-quality technology into your daily routine, supporting long-term skin health as part of a comprehensive, pro-aging approach to care.
Tap the link in our bio learn more or ask our team if this at-home LED treatment is right for you.
𝐌𝐢𝐜𝐫𝐨𝐋𝐢𝐩𝐨 𝐭𝐨 𝐭𝐡𝐞 𝐀𝐫𝐦𝐬
MicroLipo is about precision. It allows us to selectively remove stubborn fat while preserving natural contours and proportions of the arm.
In these cases, the results are not about aggressive fat removal or chasing an overly thin look. The goal is balance and refinement.
By combining MicroLipo with surgical microneedling, we are able to address both shape and skin quality. Fat is carefully sculpted, while microneedling stimulates collagen to improve texture, firmness, and overall smoothness.
The outcome is arms that look more defined, smoother, and naturally proportionate to the body.
To learn if MicroLipo to the arms is right for you, schedule a consultation at the link in bio.
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Aesthetic and Longevity Healthcare
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PFRANKMD| The Most Cutting-Edge Technologies| Customized Signature Treatments| Only Licensed Healthcare Professionals
𝐂𝐎𝟐 𝐋𝐚𝐬𝐞𝐫 𝐯𝐬 𝐌𝐢𝐫𝐢𝐚: 𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐀𝐜𝐧𝐞 𝐒𝐜𝐚𝐫 𝐎𝐩𝐭𝐢𝐨𝐧𝐬
@dr.connieyang breaks down two of our most effective options for acne scarring. The CO2 laser is the gold standard for deeper collagen remodeling and more dramatic textural improvement, though it comes with a longer recovery. Miria is a novel non-ablative laser that offers controlled resurfacing with less aggressiveness and shorter downtime.
Both options can be transformative when used thoughtfully and in expert hands. At PFRANKMD, our goal is always to match the right device to the right patient for the safest, most effective pro-aging outcome.
𝐓𝐚𝐩 𝐭𝐡𝐞 𝐥𝐢𝐧𝐤 𝐢𝐧 𝐛𝐢𝐨 𝐨𝐫 𝐜𝐚𝐥𝐥 (212) 327-2919 to schedule a consultation.
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Aesthetic and Longevity Healthcare
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PFRANKMD| The Most Cutting-Edge Technologies| Customized Signature Treatments| Only Licensed Healthcare Professionals
Frequently Asked Questions: Peptide Therapy at PFRANKMD
What are peptides and how do they work?
Peptides are small chains of amino acids that act as messengers in the body, instructing cells to carry out specific functions like healing, repair, or hormone release.
Are peptides safe?
Yes. When prescribed and administered under medical supervision using pharmacy-grade sources, peptides are generally well-tolerated and have low risk of adverse effects.
How long does it take to see results from peptide therapy?
Most patients begin noticing changes within a few weeks. Full benefits are typically experienced after 8–12 weeks of consistent use.
Can peptides help with weight loss?
Yes. Certain peptides such as CJC-1295, Tesamorelin, and GLP-1 analogs can support fat loss, improve metabolism, and regulate appetite.
Do I need lab work before starting peptide therapy?
Yes. A full health evaluation, including lab testing, helps ensure your treatment plan is safe, targeted, and effective.
Is peptide therapy only for older adults?
No. Peptide therapy can benefit adults of any age who are seeking to enhance their wellness, athletic performance, skin health, or recovery.
How is peptide therapy different at PFRANKMD?
Our approach is precision-based, backed by the latest longevity research, and delivered under the guidance of leading medical experts in the field of aesthetic and functional wellness.